Errata

Liu, X., Milo, M., Lawrence, N. D. and Rattray, M. (2006) Probe-level measurement error improves accuracy in detecting differential gene expression, Bioinformatics, 22(17):2107-2113. (Journal link)

The error bars in Figure 2 were incorrectly calculated. The posterior variance was used instead of the posterior standard deviation to compute the credibility intervals. The ranking was correct in both plots. Here is the revised figure 2. There are now 7 false positives in the top 50 genes ranked by differential expression in the left-hand plot. None of the main quantitative results in the paper (i.e. PPLR values, ROC plots, AUC scores) are affected. The main point is that ranking by differential expression alone leads to many false positives while using the PPLR criterion will greatly reduce the number of false positives. This conclusion remains valid.

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